As 1 of 10 selected workshop clusters for the 2010 Smart Geometry conference, this workshop situated itself at the nexus between architecture and systems biology to gain insight into dynamic living systems for the development of novel computational design tools and material systems that are at once natural and artificial. Generative design techniques emerge with references to natural systems, not as mimicry but as trans-disciplinary translation of flexibility, adaptation and complexity into realms of architectural manifestation. Systems Biology is a new field that focuses on the systematic study of complex interactions in biological systems, thereby using a new perspective (integration instead of reduction) to study them. This approach examines the nature of nonlinearities, emergent properties and loosely coupled modules that are cardinal features of 'complexity’. Design tools found useful in analyzing nonlinear biological systems provide new models for addressing contextual topics such as performance and change in architecture. Through the analysis of biological design problems in specialized 3D designer microenvironments, students were exposed to new modes of thinking about design ecology through an understanding of how dynamic and environmental feedback specifies structure, function and form. This workshop consisted of two parts: 1) Scripting and Simulation 2) Fabrication and Production of a 1:1 physical structure composed of 3D printed components and connections. Select results from the workshop were featured in an exhibition titled Working Prototypes at DHUB, a contemporary design museum in Barcelona, Spain.